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31.
Nicolas Merener Ramiro Moyano Nicolas E Stier-Moses Pablo Watfi 《The Journal of the Operational Research Society》2016,67(1):114-126
We develop and implement a model for a profit maximizing firm that provides an intermediation service between commodity producers and commodity end-users. We are motivated by the grain intermediation business at Los Grobo—one of the largest commodity-trading firms in South America. Producers and end-users are distributed over a realistic spatial network, and trade with the firm through contracts for delivery of grain during the marketing season. The firm owns spatially distributed storage facilities, and begins the marketing season with a portfolio of prearranged purchase and sale contracts with upstream and downstream counterparts. The firm aims to maximize profits while satisfying all previous commitments, possibly through the execution of new transactions. Under realistic constraints for capacities, network structure and shipping costs, we identify the optimal trading, storing and shipping policy for the firm as the solution of a profit-maximizing optimization problem, encoded as a minimum cost flow problem in a time-expanded network that captures both geography and time. We perform extensive numerical examples and show significant efficiency gains derived from the joint planning of logistics and trading. 相似文献
32.
33.
Analysing traces of autoinducer-2 requires standardization of the <Emphasis Type="Italic">Vibrio harveyi</Emphasis> bioassay 总被引:1,自引:0,他引:1
Vilchez R Lemme A Thiel V Schulz S Sztajer H Wagner-Döbler I 《Analytical and bioanalytical chemistry》2007,387(2):489-496
Autoinducer-2 (furanosyl borate diester) is a biologically active compound whose role as a universal bacterial signalling
molecule is currently under intense investigation. Because of its instability and the low concentrations of it found in biological
samples, its detection relies at present on a bioassay that measures the difference in the timing of the luminescence of the Vibrio harveyi BB170 sensor strain with and without externally added AI-2. Here we systematically investigated which parameters affected
the fold induction values of luminescence obtained in the bioassay and developed a modified protocol. Our experiments showed
that growth and luminescence of V. harveyi BB170 are strongly influenced by trace elements. In particular, addition of Fe3+ within a certain concentration range to the growth medium of the preinoculum culture improved the reproducibility and reduced
the variance of the bioassay. In contrast, trace elements and vitamins introduced directly into the bioassay caused inhibitory
effects. The initial density and luminescence of the sensor strain are very important and the values required for these parameters
were defined. Borate interferes with the detection of AI-2 by giving false positive results. The response of V. harveyi BB170 to chemically synthesized AI-2 in the bioassay is nonlinear except over a very small concentration range; it is maximum
over three orders of magnitude and shows inhibition above 35 μM. Based on the modified protocol, we were able to detect AI-2
in the absence of inhibitors with maximum fold induction values for the positive control (chemically synthesized AI-2) of
>120 with a standard deviation of ~30% in a reliable and reproducible way. 相似文献
34.
Jorge Soto‐Delgado Luis R. Domingo Ramiro Araya‐Maturana Renato Contreras 《Journal of Physical Organic Chemistry》2009,22(6):578-584
The polar Diels–Alder (DA) reactions of 2‐acetyl‐1,4‐benzoquinone (acBQ) with methyl substituted 1,3‐butadienes have been studied using DFT methods at the B3LYP/6‐31G(d) level of theory. These reactions are characterized by a nucleophilic attack of the unsubstituted ends of the 1,3‐dienes to the β conjugated position of the acBQ followed by ring‐closure. The reactions present a total regioselectivity and large endo selectivity. The analysis based on the global electrophilicity of the reagents at the ground state, and the natural bond orbital (NBO) population analysis at the transition states correctly explain the polar nature of these cycloadditions. The large electrophilic character of acBQ is responsible for the acceleration observed in these polar DA reactions. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
35.
Jesús Guillermo Soriano‐Moro Gabriel Jaramillo‐Soto Ramiro Guerrero‐Santos Eduardo Vivaldo‐Lima 《大分子反应工程》2009,3(4):178-184
Calculations of polymerization kinetics and molecular weight development in the dithiolactone‐mediated polymerization of styrene at 60 °C, using 2,2′‐azobisisobutyronitrile (AIBN) as initiator and γ‐phenyl‐γ‐butirodithiolactone (DTL1) as controller, are presented. The calculations were based on a polymerization mechanism based on the persistent radical effect, considering reverse addition only, implemented in the PREDICI® commercial software. Kinetic rate constants for the reverse addition step were estimated. The equilibrium constant (K = kadd/k‐add) fell into the range of 105–106 L · mol?1. Fairly good agreement between model calculations and experimental data was obtained.
36.
Ramiro Varela Camino R. Vela Jorge Puente María Sierra Inés González-Rodríguez 《Annals of Operations Research》2009,166(1):125-146
We confront a practical cutting stock problem from a production plant of plastic rolls. The problem is a variant of the well-known
one dimensional cutting stock, with particular constraints and optimization criteria defined by the experts of the company.
We start by giving a problem formulation in which optimization criteria have been considered in linear hierarchy according
to expert preferences, and then propose a heuristic solution based on a GRASP algorithm. The generation phase of this algorithm
solves a simplified version which is rather similar to the conventional one dimensional cutting stock. To do that, we propose
a Sequential Heuristic Randomized Procedure (SHRP). Then in the repairing phase, the solution of the simplified problem is
transformed into a solution to the real problem. For experimental study we have chosen a set of problem instances of com-mon
use to compare SHRP with another recent approach. Also, we show by means of examples, how our approach works over instances
taken from the real production process.
All authors are supported by MEC-FEDER Grant TIN2007-67466-C02-01 and by contract CN-05-127 of the University of Oviedo and
the company ERVISA, and by FICYT under grant BP04-021. 相似文献
37.
M. Jubera J. Villarroel A. García-Caba?es M. Carrascosa J. Olivares F. Agullo-López A. Méndez J. B. Ramiro 《Applied physics. B, Lasers and optics》2012,107(1):157-162
The propagation losses (PL) of lithium niobate optical planar waveguides fabricated by swift heavy-ion irradiation (SHI),
an alternative to conventional ion implantation, have been investigated and optimized. For waveguide fabrication, congruently
melting LiNbO3 substrates were irradiated with F ions at 20 MeV or 30 MeV and fluences in the range 1013–1014 cm−2. The influence of the temperature and time of post-irradiation annealing treatments has been systematically studied. Optimum
propagation losses lower than 0.5 dB/cm have been obtained for both TE and TM modes, after a two-stage annealing treatment
at 350 and 375∘C. Possible loss mechanisms are discussed. 相似文献
38.
M. Carmen Maestro José Antonio Fernández-Salas José L. García Ruano Oney O. Ramírez-Rodríguez Ramiro Araya-Maturana 《Tetrahedron》2012,68(22):4129-4137
The ability of a homochiral sulfinyl group at the dienophile to act as a remote stereocontrol inductor in the Diels–Alder reaction with cyclopentadiene has been evaluated. High pressure conditions were required for the reactions of (S)-2-(p-tolylsulfinyl)styrenes 3–5 (E-1,2-disubstituted double bond) and 6–8 (1,1-disubstituted double bond). A good facial selectivity and total endo selectivity were attained with 1,1-disubstitued dienophiles, though the 1,2-disubstituted ones afforded poorer results. In contrast, (S)-[2-(p-tolylsulfinyl)phenyl] vinyl ketones 9–11 reacted readily at low temperature (?40 °C) with complete endo selectivity and high facial selectivity in the presence of Yb(OTf)3 as a chelating reagent of sulfinyl and carbonyl oxygen atoms. Concerning furan reactions, β-trifluoromethyl enone 14 afforded Diels–Alder adducts with high facial selectivity in the presence of the Lewis acid, but β-non-substituted enones 9 and 12 yielded products of furan conjugate addition to the double bond. 相似文献
39.
Pessoa-Mahana H Núñez CU Araya-Maturana R Barría CS Zapata-Torres G Pessoa-Mahana CD Iturriaga-Vasquez P Mella-Raipán J Reyes-Parada M Celis-Barros C 《Chemical & pharmaceutical bulletin》2012,60(5):632-638
A series of 3-[3-(4-aryl-1-piperazinyl)-propyl]-1H-indole derivatives (12a-h) was synthesized and evaluated for binding affinity at the human 5-hydroxytryptamine(1A) receptor (5-HT(1A)R) compounds (12b) and (12h) showed the highest 5-HT(1A) receptor affinity (IC(50)=15 nM). Molecular docking studies with all the compounds in a homology model of 5-HT(1A) showed that the main interaction anchoring the ligand in the receptor was a charge-reinforced bond between the protonated nitrogen atom (N-4) of the piperazine ring and Aspartate(3.32). 相似文献
40.
Francisco J. Enríquez‐Medrano Martín Hernández‐Valdez Hortensia Maldonado‐Textle Patrick Lacroix‐Desmazes Ramiro Guerrero‐Santos 《先进技术聚合物》2012,23(3):375-381
S‐allyl‐4‐methyldithiobenzoate was synthesized and used as a chain transfer agent for the RAFT polymerization of butyl acrylate to produce a functionalized acrylic rubber. A solution of 8 wt% of this functionalized rubber was prepared in styrene and polymerized to generate a material called acrylic rubber‐modified polystyrene (AMP) constituted by well‐dispersed particles of poly(butyl acrylate)‐block‐poly(styrene) into a polystyrene matrix. Impact strength of injection‐molded samples of AMP was measured and compared with the general purpose polystyrene (GPPS) and the high impact polystyrene (HIPS). AMP itself showed an impact strength value similar to GPPS; however, when AMP was blended with conventional HIPS, the resulting material exhibited an improvement of 76–91% as compared to HIPS by itself, without affecting negatively tensile properties. Transmission electron microscopy analysis revealed both kinds of dispersed phases, i.e. the typical salami particles of polybutadiene coming from HIPS (size: 0.5–2 µ) and small particles from poly(butyl acrylate)‐block‐poly(styrene) (size: ~50 nm). We clearly showed that such a bimodality of the particle size distribution caused the positive synergistic effect on impact strength. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献